miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
نویسندگان
چکیده
منابع مشابه
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
SIRT1 is increasingly recognized as a critical regulator of stress responses, replicative senescence, inflammation, metabolism, and aging. SIRT1 expression is regulated transcriptionally and post-transcriptionally, and its enzymatic activity is controlled by NAD+ levels and interacting proteins. We found that SIRT1 protein levels were much higher in mouse embryonic stem cells (mESCs) than in di...
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ژورنال
عنوان ژورنال: Aging
سال: 2010
ISSN: 1945-4589
DOI: 10.18632/aging.100176